Feature article: Amorphous Solid Dispersion Speciation - Impact of Polymer Chemistry & Drug Properties
Home
Knowledge Center
Feature article: Amorphous Solid Dispersion Speciation - Impact of Polymer Chemistry & Drug Properties

Feature article: Amorphous Solid Dispersion Speciation - Impact of Polymer Chemistry & Drug Properties

The amorphous state is a high-energy physical form that can enhance solubility beyond that of crystalline forms. In an ASD, API is typically for­mulated with a polymer that helps to both maintain the API in the amorphous form in the solid state and may act as a precipitation inhibitor to sustain the amorphous solubility upon dissolution.

Formulation development of ASDs focuses on polymer se­lection, the ratio of drug to polymer, and the design of the ASD particles to develop a system that is physically stable while also demonstrating optimal performance. ASD performance is defined by enhancement in bioavailability, driven by supersaturation of dissolved drug and the formation of drug-polymer colloids. This article focuses on the use of in vitro techniques for character­izing ASD performance and on how these techniques can be used to help better understand the role of polymer chemistry in ASD performance. READ NOW >

Read Article

About Serán

Serán BioScience, LLC, is a science-driven Drug Development Partner, recognized as a world leader in drug development. Utilizing a foundation of physical and chemical science, Serán designs robust formulations and engineered solutions to some of the industry's toughest drug product problems. Our experience and background cover a wide range of pharmaceutical manufacturing concepts bringing our world-class expertise to you and your drug product. Serán’s team has decades of experience developing complex drug molecules into enabling medicines. With every addition to our team, we further our commitment to our clients’ success. From preclinical to GMP and beyond, Serán is here to support you and your drug product every step of the way.

For more information, visit www.Seranbio.com or email us at hello@seranbio.com.

Contact

Serán BioScience, LLC
63047 Layton Ave, Bend, OR 97701 USA
www.seranbio.com

Ready to get started?

Our experience and background cover a wide range of pharmaceutical manufacturing concepts bringing our world-class expertise to you and your drug product.