CRBE Summit East

Crown Plaza Princeton

Princeton, NJ

Uncover industry’s latest formulation, product development and delivery technologies for improving performance and manufacturing capabilities.

Serán is proud to sponsor this year's CRBE Summit East!

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PRESENTATION:

Beyond Solubility - a new pharmaceutical classification guiding enabled formulations in the modern molecular landscape

Modern drug development faces a significant challenge as over 70% of new pharmaceutical compounds struggle with low solubility. A novel classification framework is introduced to improve the design of enabled formulations, specifically focusing on amorphous solid dispersions. This system moves past basic solubility issues to evaluate how and when to consider the impact of dissolution and diffusion as rate limiting steps to absorption. By categorizing these complex molecular properties, the framework helps researchers determine how to optimize their amorphous formulation for optimal performance. Ultimately, this approach provides a sophisticated strategy for optimizing bioavailability in an increasingly complex chemical landscape.

· With over 70% of new drugs being solubility-limited, rising molecular complexity requires advanced bioavailability enhancement strategies.

· Amorphous solid dispersions (ASDs) remain a leading solution, yet their application must evolve alongside modern chemical properties.

· A new classification system guides formulation design by identifying when to optimize beyond basic solubility to consider dissolution rate, the formation of solubilized species, or to consider the addition of permeation enhancers.

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