Disso America 2026

The Palace at Somerset Park

Somerset, NJ

June 16-17

Disso America 2026 is a live, two-day workshop organized by the US Chapter of the Society for Pharmaceutical Dissolution Science (SPDS), bringing together global experts from industry, academia and regulatory agencies to advance the science of dissolution and drug delivery. Four focused sessions featuring global experts from industry, academia and regulatory bodies. Speakers will share real-world strategies and perspectives on formulation development, predictive dissolution, regulatory consideration, and special dosage forms - all within a collaborative, interactive environment.

Explore cutting-edge ideas, emerging results, and innovative approaches during the interactive poster session. Meet presenters face-to-face, ask questions, and dive deeper into work that's shaping the field at your own pace.

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SERÁN POSTER PRESENTATION:

Influence of Particle Morphology on Amorphous Solid Dispersion Drug Product Design 

Spray dried dispersions (SDDs)and hot-melt extrusions (HMEs) are common amorphous solid dispersions (ASDs) used as drug product intermediates in oral dosage forms. While these techniques can create compositionally equivalent ASDs, the physical attributes of these dispersions can impact the formation of drug-polymer colloids and performance of the ASD in vitro and in vivo. 

Biorelevant dissolution is used to evaluate the formation of drug-polymer colloids from ASD powders and formulated tablets in vitro, and are critical for designing, understanding, and optimizing these formulations. To clarify the effects of ASD particle properties on dissolution and speciation, two ASD formulations were manufactured with itraconazole (ITZ) as an SDD and HME and were compared by two-stage biorelevant dissolution. Additionally, these ASDs were incorporated into fully formulated tablets to evaluate the impact of incorporation into a tablet on colloidal formation. 

Manufacturing technology had a significant impact on the extent of colloidal species formation for HPMCAS-M. The smaller, less dense SDDs were able to form significantly more drug-polymer colloids than their HME counterparts. This can be attributed to the effect of particle size on dissolution rate which, in turn, influences the congruent dissolution needed for drug-polymer colloid formation.

Presented by: Max Frisbie, Scientist II

Join us to learn more!

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